How much is Clemson favored to win Saturday’s game vs. Duke at Memorial Stadium?

The Tigers (3-4, 2-3 ACC) open as a 3.5-point favorite over the Blue Devils (4-3, 3-1 ACC), according to FanDuel Sportsbook.

The contest is set to kick off at noon and will be televised on ACC Network.

Clemson is 37-17 all-time against Duke, including a 20-4-1 mark at Death Valley. The two teams most recently met to open the 2023 season, with Duke winning 28-7 in Durham.  

The game will mark Clemson’s first time hosting the Blue Devils since 2018, when the Tigers defeated quarterback Daniel Jones’ Duke squad 35-6 amid the Tigers’ 15-0 national championship season.

Both Clemson and Duke had open dates this weekend. Clemson is coming off a 35-24 home loss to SMU on Saturday, Oct. 18, while Duke suffered a 27-18 home loss to undefeated Georgia Tech on the same day.

When it hosts Duke, Clemson will try to win its first game against a Power 4 team at Memorial Stadium since Oct. 19, 2024 against Virginia.