Clemson is slightly favored to win Saturday’s game vs. Florida State at Memorial Stadium.

The Tigers (3-5, 2-4 ACC) open as a 2.5-point favorite over the Seminoles (4-4, 1-4 ACC), according to FanDuel Sportsbook.

The contest is set to kick off at 7 p.m. and will be televised on ACC Network.

Clemson is 16-21 all-time against Florida State, including a 9-9 mark at Death Valley. Last season, the Tigers beat the Seminoles, 29-13, in Tallahassee.

Clemson has won eight of its last nine meetings with Florida State, including four straight wins in Tallahassee and a 4-1 mark at Death Valley.  FSU won the most recent meeting at Clemson – 31-24 in overtime on Sept. 23, 2023.

Clemson is coming off a 46-45 home loss to Duke on Saturday, while Florida State rolled to a 42-7 home win over Wake Forest on Saturday. It marked the Noles’ first ACC win since beating Cal last season on Sept. 21, 2024.

When it hosts FSU, Clemson will try to win its first game against a Power 4 team at Memorial Stadium since Oct. 19, 2024 against Virginia.