A former Clemson wideout is back in the NFL.

The Buffalo Bills announced Monday they have signed Deon Cain to a one-year deal.

Back on Oct. 31 of 2024, the Bills signed Cain to their practice squad before later cutting him in early December. He was on the Bills’ 2024 preseason roster and posted three receptions for 28 yards against the Carolina Panthers.

A 2018 sixth-round pick of the Indianapolis Colts, Cain’s most recent NFL regular season playing time came in 2020 when he was a member of the Pittsburgh Steelers. Along with the Bills, Colts and Steelers, Cain has spent time with the Panthers, Baltimore Ravens and Philadelphia Eagles in his NFL career. He has appeared in 15 career games (six starts) and caught nine passes for 124 yards in his NFL career.

Cain has shined while playing for the Birmingham Stallions, helping them win the 2024 UFL Championship and the 2023 USFL Championship. The former All-ACC selection caught three touchdown passes en route to USFL Championship Game MVP honors back in July 2023, and he was named to the 2025 All-UFL Team after racking up 29 receptions for 514 yards and six touchdowns in nine games.

This year, Cain ranked third in the UFL in receiving yards, while he was second in the league in receiving touchdowns and also fifth in the league with 421 kick return yards.

In his career at Clemson from 2015-17, Cain hauled in 130 receptions for 2,040 yards and 20 touchdowns over 42 games (14 starts). The Tampa, Fla., native had at least one reception in each of the last 37 games he played.

Cain burst onto the scene as one of Clemson’s biggest downfield threats as a true freshman in 2015, and he was a third-team All-ACC honoree in his final year as a Tiger in 2017, when he recorded 58 receptions for 734 yards and six touchdowns over 14 games.