CBS Sports recently broke down this year’s ACC football schedule, projecting the first loss for every team in the conference.

The outlet sees Clemson getting past LSU in the season opener and then running the table the rest of the way – that is, until the regular season finale at rival South Carolina.

CBS Sports predicts an 11-0 start for the Tigers before they eventually suffer a loss against the Gamecocks in Columbia on Nov. 29.

Should that happen, it would end Clemson’s streak of five straight wins on the road against South Carolina dating back to 2015.

“That’s right. The Gamecocks could potentially spoil an unbeaten regular season for Dabo Swinney and the Tigers,” CBS Sports’ Brad Crawford wrote. “South Carolina handed Clemson one of its four losses last fall with two others coming to additional SEC teams. South Carolina hasn’t beaten Clemson at home since the 2013 season with the Gamecocks’ only two wins in the series since each coming on the road. Even if Clemson suffers a letdown in the Palmetto State rivalry, the Tigers could be the top seed in the playoff if they’re able to win the ACC championship the following week.”

FanDuel Sportsbook has Clemson as an early 4.5-point favorite against South Carolina.

Meanwhile, CBS Sports predicts Clemson to hand a pair of ACC foes their first loss of the 2025 season – first, Georgia Tech in the two teams’ conference opener on Sept. 13 in Atlanta.

“Getting past Colorado on the road to open the season on Aug. 29 will not be easy for Brent Key’s program, but there are less questions surrounding the Yellow Jackets than the Buffaloes at this point,” Crawford wrote. “Now, beating Clemson for the first time since 2015 is a different task entirely. Georgia Tech’s bread is buttered up front with veterans across the offensive line, but the Tigers have two potential future first-round draft picks in this one chasing Haynes King throughout — defensive tackle Peter Woods and edge rusher T.J. Parker.”

Clemson’s last road game at Georgia Tech was played at Mercedes Benz Stadium in 2022, so this year’s contest will mark the Tigers’ first trip to Bobby Dodd Stadium since 2020, a game in which Trevor Lawrence threw for 404 yards and five touchdowns in a 73-7 win, the largest margin of victory in an ACC game in conference history.

Clemson is also projected to deal SMU its first defeat of the upcoming campaign when the two teams clash on Oct. 18 at Death Valley in a rematch of last year’s ACC Championship Game thriller.

“A highly-anticipated rematch of last season’s conference title game, there’s a chance the Mustangs travel to Death Valley in mid-October sporting an unblemished record and top 10 ranking following early tests against Baylor and TCU,” Crawford wrote. “This is the first of three regular-season games we’re expecting to come against nationally-ranked competition for Rhett Lashlee’s squad.”

That game against SMU will be Clemson’s lone home game in the month of October. Nolan Hauser’s 56-yard walk-off field goal in last year’s ACC title game victory over SMU gave Clemson its record 22nd ACC title and sent the Tigers to their seventh College Football Playoff.