Clemson is an underdog entering its road game against Louisville on Friday night.

The Cardinals (7-2, 4-2 ACC) open as a 3.5-point favorite over the Tigers (4-5, 3-4 ACC), according to FanDuel Sportsbook.

The contest is set to kick off at 7:30 p.m. and will be televised on ESPN.

The Cardinals earned their first win against the Tigers in series history last season with a 33-21 win at Clemson’s Memorial Stadium. However, Clemson remains 4-0 in road games at Louisville, including most recently a 30-24 victory in 2021 in which the Tigers held the Cardinals out of the end zone on four straight downs from the Clemson 2-yard line in the final minute for the win.

Clemson leads the all-time series with Louisville, 8-1.

Clemson is coming off a 24-10 home win over Florida State on Saturday – snapping a six-game losing streak against Power 4 teams at Death Valley — while Louisville suffered a major upset loss on Saturday, falling 29-26 at home to Cal (6-4, 3-3 ACC) in overtime. The Cardinals were favored by 18.5 points entering that contest.

After Clemson wraps up its 2025 ACC schedule at Louisville, the Tigers will return home to face Furman on Saturday, Nov. 22, before closing out the regular season against rival South Carolina in Columbia on Saturday, Nov. 29.