The early betting line for Clemson’s 2026 season opener has been released.

Clemson is a 10.5-point underdog against LSU, according to FanDuel Sportsbook.

Clemson and LSU will kick off their respective 2026 seasons on Sept. 5, when the two teams face off at Tiger Stadium in Baton Rouge, La.

Clemson and LSU faced one another at neutral sites in postseason play four times before the two sets of Tigers met in Clemson in the 2025 season opener for their first regular season, on-campus meeting in series history – what was a top-10 matchup that saw LSU win, 17-10, at Memorial Stadium.

LSU leads the all-time series against Clemson 4-1, with Clemson’s lone win being a dramatic 25-24 victory in the 2012 Peach Bowl.

The 2026 opener will mark Clemson’s first trip to Baton Rouge and Clemson’s first time opening a season in an SEC venue since opening its 2016 national championship season with a 19-13 win at Auburn.

It will also be Lane Kiffin’s first game as LSU’s head coach after he was hired this past November to replace Brian Kelly, who was fired in October.

“I know Lane professionally,” Clemson head coach Dabo Swinney said in December. “We’ve text many times over the years. He’s reached out different times, questions, or whatever. So, obviously he’s a great coach, and that’s a great program. When that time comes, it’ll be a great matchup.”